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Anabolic Steroids Effects on Bone Regeneration

Received: 9 June 2019     Accepted: 16 July 2019     Published: 30 July 2019
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Abstract

In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.

Published in American Journal of Sports Science (Volume 7, Issue 3)
DOI 10.11648/j.ajss.20190703.12
Page(s) 88-93
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Anabolic Steroids, Testosterone, Fracture Fibula, Bone Regeneration

References
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Cite This Article
  • APA Style

    José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. (2019). Anabolic Steroids Effects on Bone Regeneration. American Journal of Sports Science, 7(3), 88-93. https://doi.org/10.11648/j.ajss.20190703.12

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    ACS Style

    José Carlos Pansieri; Alessandra Esteves; Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am. J. Sports Sci. 2019, 7(3), 88-93. doi: 10.11648/j.ajss.20190703.12

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    AMA Style

    José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior. Anabolic Steroids Effects on Bone Regeneration. Am J Sports Sci. 2019;7(3):88-93. doi: 10.11648/j.ajss.20190703.12

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  • @article{10.11648/j.ajss.20190703.12,
      author = {José Carlos Pansieri and Alessandra Esteves and Wagner Costa Rossi Junior},
      title = {Anabolic Steroids Effects on Bone Regeneration},
      journal = {American Journal of Sports Science},
      volume = {7},
      number = {3},
      pages = {88-93},
      doi = {10.11648/j.ajss.20190703.12},
      url = {https://doi.org/10.11648/j.ajss.20190703.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajss.20190703.12},
      abstract = {In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Anabolic Steroids Effects on Bone Regeneration
    AU  - José Carlos Pansieri
    AU  - Alessandra Esteves
    AU  - Wagner Costa Rossi Junior
    Y1  - 2019/07/30
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajss.20190703.12
    DO  - 10.11648/j.ajss.20190703.12
    T2  - American Journal of Sports Science
    JF  - American Journal of Sports Science
    JO  - American Journal of Sports Science
    SP  - 88
    EP  - 93
    PB  - Science Publishing Group
    SN  - 2330-8540
    UR  - https://doi.org/10.11648/j.ajss.20190703.12
    AB  - In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.
    VL  - 7
    IS  - 3
    ER  - 

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Author Information
  • Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil

  • Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil

  • Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil

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